PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.
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National Center for Biotechnology InformationU. Genetic epidemiology of breast cancer: See Am J Hum Genet. Open kinkage a separate window.
Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.
– Document – Linkage of early-onset familial breast cancer to chromosome 17q21
Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.
Am J Hum Genet. Familial breast-ovarian cancer locus on chromosome 17qq Estimating the power of linkage analysis ewrly-onset hereditary breast cancer. Inheritance of proliferative breast disease in breast cancer kindreds.
However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested. Genetic epidemiology of breast cancer in Britain.
There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset.
This article has been cited by other articles in PMC. This article has been corrected. Support Center Support Center. Inheritance of human breast cancer: A new statistical test for linkage heterogeneity. Segregation yo linkage analysis of nine Utah breast cancer pedigrees. Genetic analysis of breast cancer in the cancer and steroid hormone study.
Linkage of early-onset familial breast cancer to chromosome 17q21.
The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.
Linkage of early-onset familial breast cancer to chromosome 17q Strategies for multilocus linkage analysis in humans. Closing in on a breast cancer gene on chromosome 17q. Author information Copyright and License information Disclaimer.