Insulin lispro protamine is used to reduce high blood sugar levels in patients Insulin lispro protamine is injected under the skin. Humalog Mix KwikPen. HUMALOG é indicado no tratamento de pacientes com diabetes mellitus que necessitam .. médico e leve a embalagem ou bula do medicamento, se possível. 18 abr. B. Humalog Mix 50 Lilly (50% lispro/protamina e 50% lispro). 2,0. .. dicado em bula, o uso combinado de exanatide com.

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After first use 28 days. The pharmacokinetics of insulin lispro reflect a compound that is rapidly absorbed, and achieves peak blood levels 30 to 70 minutes following subcutaneous injection.

Insulin lispro takes effect rapidly and has a shorter duration of activity 2 to 5 hours when compared to soluble insulin. The time course of insulin lispro hhmalog may vary in different individuals or at different times in the same individual and is dependent on dose, site of injection, blood supply, temperature and physical activity.

Humalog 200 Units/ml KwikPen, solution for injection in pre-filled pen

Hypoglycaemia may occur as a result of an excess of insulin activity relative to food intake and energy expenditure. The number of insulin units is shown in the dose window of the pen regardless of bul and no dose conversion should humaalog done when transferring a patient to a new strength or to a pen with humalogg different dose step.

However, glucose solution must be given intravenously if glucagon is not available or if the patient fails to respond to glucagon. It may cause a rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Transferring a patient to another type or brand of insulin should be done under strict medical supervision.

Detailed information on this medicinal product is available on the website of the European Medicines Agency http: Local allergy in patients is common.

Studies also demonstrate that the dissociation of binding uumalog the insulin receptor of insulin lispro is equivalent to human insulin. Before use 3 years.


The patient should discard the needle after every injection. This condition usually resolves in a few days to a few weeks. Name of the medicinal product 2. Humalog may be given shortly before meals.

Send coupon directly to your phone. If the combination is used, patients should be observed for signs and symptoms of heart failure, weight gain and oedema.

When necessary Humalog can be given soon after meals. Do not expose to excessive heat or direct sunlight. Within muscle tissue this includes increasing glycogen, fatty acid, glycerol and protein synthesis and amino acid uptake, while decreasing glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism and amino acid output.

Insulin requirements and dosage adjustment Insulin requirements may be increased during illness or emotional disturbances. View our Humalog coupons and manufacturer promo offers. Glucodynamic differences between insulin lispro and soluble human insulin, as measured during a glucose clamp procedure, were maintained over a wide range of renal function.

Enter medicine name or company Start typing to retrieve search suggestions. Yellow Card Scheme, website: Fertility Insulin lispro did not induce fertility impairment in animal studies see section 5. Customer Service Use ref Contact Form. Hypoglycaemia and hyperglycaemia Conditions which may make the early warning symptoms of hypoglycaemia different or less pronounced include long duration of diabetes, intensified insulin therapy, diabetic nerve disease or medicinal products such as beta-blockers.

This medicinal product contains less than 1 mmol sodium 23 mg per dose, i.

The solution for injection should not be diluted. In in vitro tests, including binding to insulin receptor sites and effects on growing cells, insulin lispro behaved in a manner that closely resembled human insulin.

Find out more here. Qualitative and quantitative composition 3. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia [see Warnings and Precautions Eli Lilly Nederland B. Hypersensitivity to the active substance or to any of the excipients listed in section 6.

Humalog should not be used if it appears cloudy, thickened, or slightly coloured or if solid particles are visible. Humalog takes effect rapidly and has a shorter duration of activity 2 to 5 hours given subcutaneously as compared with soluble insulin.


The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. Special populations Renal impairment Insulin requirements may be reduced in the presence of renal impairment. If the patient is comatose, glucagon should be administered intramuscularly or subcutaneously. Patients with diabetes should be advised to inform their doctor if they are pregnant or are contemplating pregnancy.

Strengths Available for Humalog |

The reduction of HbA1c would also be expected with other insulin products e. Careful monitoring hmalog glucose control, as well as general health, is essential in pregnant patients with diabetes.

The patient should be given a meal as soon as consciousness is recovered. This may constitute a risk in situations where these abilities are of special importance e. Combination of Humalog with pioglitazone Cases of cardiac failure have been reported when pioglitazone was used in combination with insulin, especially in patients with risk factors for development of cardiac heart failure.

Patients should be advised to take precautions to avoid hypoglycaemia whilst driving. Transferring a patient to another type or brand of insulin Transferring a patient to another type or brand of insulin should be done under strict medical supervision. Patients must visually verify the dialled units on the dose counter of the pen. This rapid onset of activity allows bila Humalog injection to be given very close to mealtime.

Correction of moderately severe hypoglycaemia can be lisrpo by intramuscular or subcutaneous administration of glucagon, followed by oral carbohydrate when the patient recovers sufficiently.

Needles are not included. In some studies, reduction of nocturnal hypoglycaemia was associated with increased episodes of daytime hypoglycaemia.

Insulin lispro maintains more rapid absorption and elimination when compared to soluble human insulin in patients with hepatic impairment.