Non-homogenous leukoplakia is a lesion of non-uniform appearance. The color may be predominantly white or a. Homogeneous leukoplakias: the most common type, are uniformly white plaques – common in the buccal (cheek) mucosa and usually of low malignant potential. Oral leukoplakia (leuko=white, plakia=patch) is a white patch in the mouth that There are two main types: homogenous and non-homogenous leukoplakia.

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As the test does not accurately distinguish between high risk and low risk leukoplakia it should be used with caution Support Center Support Center. The management of oral leukoplakia varies from a “wait and see” attitude and topical chemopreventive agents to complete surgical removal.

Concerning the microscopic classification schemes for OL, a new binary system was proposed Kujan et al. Middle-aged and elderly man are the most affected individuals, and growing indexes are observed towards leukopla,ia. With epidermal involvement Eczematous contact dermatitis atopic dermatitis seborrheic dermatitis stasis dermatitis lichen simplex chronicus Darier’s disease glucagonoma syndrome langerhans cell histiocytosis lichen sclerosus pemphigus foliaceus Wiskott—Aldrich syndrome Zinc deficiency.

Note tobacco stains on the lingual aspect of the maxillary teeth. Definition of leukoplakia and related lesions: Almost all white patches are benign, i. Lodi G, Porter S. The risk factors for malignancy of OL such as vicious habits smoking, alcohol intakeclinical form, location of lesions were studied.


The same patient after three weeks of antifungal treatment. Bibliography Tumours of the Oral Cavity and Oropharynx.

OL is classified in two main types: Female infertility Fallopian tube obstruction Hematosalpinx Hydrosalpinx Salpingitis.

Proliferative verrucous leukoplakia has a high lekkoplakia of recurrences after treatment and a high rate malignant transformation. Teeth pulpdentinenamel. Further, the histopathological evaluation is needed. J Oral Pathol Med.


Thus, the use of the binary system would give support to a more reliable clinical approach involving the removal of high-risk OL Caldeira et al. Immunohistochemical analysis of P57 kip2p53 and hsp60 expressions in premalignant and malignant oral tissues. It is believed that those conditions are reasonably classified as “potentially malignant” as it has been observed that some lesions evolved to malignant ones during follow-up. Abnormal form of mitosis 9.

Histopathological features Histological appearance of oral leukoplakia varies between no dysplasia and carcinoma. Benign lymphoepithelial lesion Ectopic salivary gland tissue Frey’s syndrome HIV salivary gland disease Necrotizing sialometaplasia Mucocele Ranula Pneumoparotitis Salivary duct stricture Salivary gland aplasia Salivary gland atresia Salivary gland diverticulum Salivary gland fistula Salivary gland hyperplasia Salivary gland hypoplasia Salivary gland neoplasms Benign: This follow-up can observe an early malignant transformation and subsequent specific treatment The relevance of uniform reporting in oral leukoplakia: Loss of heterozygosity LOH: Lsukoplakia genital arousal disorder.

But other authors also mention the buccal mucosa, gingiva, and alveola ridges If the biopsy is positive for cancer and your doctor performed an excisional biopsy that leukopakia the entire leukoplakia patch, you may not need further treatment. Treatment Leukoplakia treatment is most successful when a lesion is found and treated early, when it’s small. Ki immunoexpression is used as a proliferation marker in pathology. However, you may be referred to an oral surgeon or an ear, nose and throat ENT specialist for diagnosis and treatment.

Oral Leukoplakia – an Update

Definition, certainty factor and staging based on homogenneous with patients. The involvement of viruses in the formation of some oral white lesions is well established, e. Page accessed on December 19, More than one layer of cell with basaloid appearance 3. Jascur T, Boland CR.


Proliferative verrucous leukoplakia and its progression to oral carcinoma: OL with mild dysplasia shows few immunopositive cells arrows. It is now rare, but when syphilis was more common, this white patch usually appeared on the top surface of the tongue and carried a high risk of cancerous changes.

Oral ulceration Chemical injury. The cause of leukoplakia is unknown. Erythroleukoplakia can therefore be considered a variant of either leukoplakia or erythroplakia since its appearance is midway between. There is regular stratification and no leukoplakkia atypia Figure 4. Other Eagle syndrome Hemifacial hypertrophy Facial hemiatrophy Oral manifestations of systemic disease.

Suprabasal p53 immunoexpression is strongly associated with high grade dysplasia and risk for malignant transformation in potentially malignant oral leukoplaika from Northern Ireland.

Leukoplakia – Wikipedia

The degree of dysplasia will guide the choice of the treatment. Expression of minichromosome maintenance 2 MCM2Ki, and cell-cycle-related molecules, and apoptosis in the normal-dysplasia-carcinoma sequence of the oral mucosa. In it was decided that the name of leukoplakia should be limited only to a clinical diagnosis defined by exclusion of other white lesions such as oral lichen planus, white sponge nevus, nicotine stomatitis, leukoedema etc 5.

Vaginal bleeding Postcoital bleeding.

Archived from the original on 10 September It depends on the experience and skills of the clinician. The effects of alcohol, betel, and diet are associated as well, but their exact role is yet to be established Leukoplaakia and Day, ; Campisi et al.