Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.

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Hence, F3 with 1. Undesirable skin changes, i.

Microemulsion formulation for enhanced absorption of poorly soluble drugs: Carrageenan induced paw evalhation model: Female wistar rats weighing g were divided into three groups. Eric Randy Reyes Politud. Herein, no further evaluation and animal studies were done to assess the implications of the formulation in vivo.

The anti-inflammatory activity was numerically more in voltaren emulgel as compared to aceclofenac emulgel.

Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.

Secondly, relevance of this fact is even more when the respective drugs are taken life-long in chronic conditions like arthritis.

Moreover, the effectiveness of the formulation in delivering the drug as manifested in vitro and ex vivo studies, was transposed into significantly mitigating inflammation in animal models.

Previous studies have attempted formulation of aceclofenac in emulgels and gels, however, the data regarding formulation of microemulsion-based emulgel of aceclofenac and head-to-head comparison of anti-inflammatory activity with the most popular marketed emulgel is not reported in the literature 15 – An effective anti-inflammatory drug is purported to act via both the pathways, thus mitigating inflammation.

Different formulations F1-F4 of Oxiconazole emulgel was prepared by using carbopol as gelling agent with varying concentrations of oily phase such as liquid paraffin and Tween and Span as a emulsifying agent.


The study also highlights preclinical analysis, that aceclofenac and diclofenac show equal efficacy when used topically. The percentage change in inflammation was calculated by the same formula as mentioned evaaluation. In an earlier study conducted by Pani et al. The animal studies were conducted in the animal house, under appropriate care and precautions.


Most remarkable finding was that the anti-inflammatory activity exhibited by aceclofenac microemulsion-based emulgel.

Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.

However, a prominent drawback in formulating gels is difficulty in delivery of hydrophobic drug. The oxiconazole used in treatment of various fungal infections such as cutaneous and subcutaneous formulatjon like acne and psoriasis.

In view of the foregoing, we attempted to formulate a microemulsion based emulgel of aceclofenac and tested the efficacy of the formulation in animal models of inflammation. The solubilization capability of aceclofenac in different oils, surfactant and co surfactant was shown in the Table 1. It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus MRSA infections. Formulation and evaluation of mefenamic acid emulgel for topical delivery.

Aceclofenac was added to it in small parts until the drug completely dissolved in the solution. The findings of formulagion study may yield further avenues for researchers as well as formulation scientists to design further studies on aceclofenac emulgel formulations, using the optimized microemulsion techniques.

The inflammation in the ear of each rat was noted using Vernier caliper at 1st, 2nd, 3rd and 4th h of treatment.

Hence, the study yields valuable insights into improving the solubility of a BCS class II drug, through a microemulsion based emulgel. Within 24 hrs from the Submission of Papers Review Notification: Microemulsion containing 15 mg of aceclofenac was evenly applied onto the surface of dialysis membrane along with aceclofenac suspension in water for comparison.

Stability studies indicated that the physical appearance, rheological properties, spreadability, drug release in all the prepared emulgels remained unchanged upon storage for 3 months Keywords Emulgep hydrochloride, CarbapolAntifungal activity, Film formation, Emulgel formulation. Formulation and evaluation of oxiconazole emulgel for topical drug delivery Author: Microemulsion formulation aids in improving the drug solubility owing to reduced particle size, improved surface tension and better permeation.


Formulation and Evaluation of Tioconazole Emulgel for Topical Drug Delivery System

The particle size and zeta potential of the microemulsion was evaluated using nano zeta sizer. The aceclofenac emulgel obtained was a white translucent gel with a pH of 6. Edema was induced in rats using 0. So, All formulatiob authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

The drug release was found to be higher for optimized formulation as compared to the marketed Terbinafine hydrochloride cream. A formulation yielding clear and transparent appearance and the one not cracking when observed for 24 h was selected for further studies.

An emergent tool in topical drug delivery. The objective to formulate an emulgel using non-irritating and pharmaceutically acceptable ingredients was achieved. All versions This version Views 81 81 E,ulgel 52 52 Data volume Hence, the emulgfl strategy for aceclofenac and thereby, an efficient drug delivery led to an effective anti-inflammatory activity. Elsadig Gasoom FadelAlla Elbashir. Wistar rats g were divided randomly into three groups. Percentage inflammation was calculated as under:.

The aim of present work was to evapuation and evaluate Oxiconazole emulgel with gormulation release. The anti-inflammatory activity of aceclofenac emulgel was evaluated using carrageenan induced paw edema in rats by a method described by Gerald et al.

After a number of trials, microemulsion of aceclofenac was optimized with: Hence, the micro emulsion was considered optimum in terms of these pharmaceutical characteristics. No allergic symptoms like inflammation, redness, irritation appeared on rats up to 24 h.