Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Diana Finzi, Joel N. Combination therapy for HIV-1 infection can reduce plasma virus to Thus, latent infection of resting CD4+ T cells provides a mechanism for lifelong persistence Diana Finzi, Joel Blankson, +14 authors Robert F. Siliciano; Published in. Due to the importance of the latent reservoir in maintaining infection despite .. the long-term persistence of latent virus in HIV-infected individuals Finzi et al.
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Virus isolated from the latent reservoir at 19 and 21 months showed multiple mutations conferring resistance to zidovudine. Toward an HIV Cure. Dornadula G, et al. Combined Modality Therapy Antiretroviral therapy. The success of combination therapy for the treatment of HIV-1 infection has resulted in a focus on sources of persistent HIV-1 in treated individuals.
Nature MedicineVol. Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy.
This article has been cited by other articles in PMC. Active nuclear infecgion of human immunodeficiency virus type 1 pre-integration complexes. In the former case, the composition of the latent reservoir should not change on therapy and should reflect the virologic status before Lattent. Patient 2 started zidovudine, lamivudine, and ritonavir at 11 months of age after having received 6 weeks of zidovudine therapy for postnatal prophylaxis.
CrandallDavid Posada Infection, genetics and evolution: If the latent reservoir consists of only 1 x 10 5 cells, eradication could take as long as 60 lateng. Numbers in the top row indicate RT codons associated with drug resistance and protease codons associated with drug resistance, common polymorphisms, or polymorphism and accessory substitutions to protease inhibitors.
After the rapid initial decay in the first 3 months of treatment, little subsequent decay is detected. Children with perinatally acquired HIV-1 infection were eligible. Chun TW, et al. A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside infecton.
Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants. Finzi D, Siliciano RF.
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Showing of extracted citations. The median age at entry was 7. Tools of the Trade Kirston M. Open in a separate window.
Viral dynamics in human immunodeficiency virus type 1 infection. Mathematical and statistical methods.
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.
N Engl J Med. How to Define the Latent Reservoir: In vivo estimates of division and death rates of human T lymphocytes. Because the MI mutation is associated with drug resistance to both didanosine and lamivudine and both children received previous nonsuppressive therapy with didanosine, then were subsequently treated with a suppressive regimen that contained lamivudine, it is not possible to determine to which drug this mutation should be attributed.
Drug-resistance mutations generated by previous nonsuppressive regimens persisted in this compartment despite more than 1 year of fully suppressive HAART, rendering untenable the idea of recycling drugs that were part of failed regimens. HIV-1 entry into quiescent primary lymphocytes: Furtado MR, et al.
The positions of the primers are numbered according to the pol gene of the HXB2R isolate http: Link to publication in Scopus. In contrast, 5 of the 6 children who were treated previously with incompletely suppressive regimens of zidovudine and didanosine and who had suppression of viral replication for 12—30 months on HAART had persistence of replication-competent HIV-1 harboring mutations conferring resistance to zidovudine and didanosine.
Table 1 Patient characteristics at entry. A priorithere are several reasons to believe that the dynamics of the latent reservoir might be different in children with perinatally acquired HIV-1 infection than in adults. Shearer WT, et al. Thus, in this patient who had clearly developed zidovudine-resistant virus and who is still on zidovudine, both zidovudine-sensitive virus and zidovudine-resistant virus can be found in the latent reservoir.
Sequencing of the HIV-1 pol gene. Perelson AS, et al.
Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate fibzi infection. This child was treated with nonsuppressive antiretroviral regimens consisting of latfnt, lamivudine, didanosine, and zalcitabine for 3. AB – Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection.
This reservoir has a biphasic decay pattern after the initiation of HAART, with a rapid initial drop in the first 3 months of therapy followed by a second phase in which there is minimal decay. Six children were receiving combination therapy with 2 nucleoside analogues and the protease inhibitor ritonavir.
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