Enrico Bucci, Temple University, Biology Department, Adjunct. Studies CONTROLLO DI NANOMACCHINE MEDIANTE CAMPI ELETTROMAGNETICI more. Ovidio M. Bucci, Franceschetti, G., Lezioni di Campi Elettromagnetici e Circuiti, 4, Antenne, –, Liguori, Naples, Italy, Kouyoumjian, R. G., P. H. De Leo (Università Politecnica delle Marche), Ovidio M. Bucci (Università di Napoli Giorgio Barzilai, professore di Campi Elettromagnetici presso l’ università.
|Published (Last):||24 December 2010|
|PDF File Size:||19.72 Mb|
|ePub File Size:||10.94 Mb|
|Price:||Free* [*Free Regsitration Required]|
Skip to main content.
Log In Sign Up. Enrico Bucci was born in Naples, Italy, in He graduated summa cum laude in Biology in University of Naple Inhe founded his first start-up, BioNucleon Srl, incubated at the Canavese Bioindustry Park and dedicated to nucleic-acid based drugs.
By the end ofafter honouring all commitments related to his previous role, Enrico Bucci moved to become CSO of Biodigitalvalley Srl, his second start-up, dedicated to bioinformatics. In Januaryhe was appointed CEO. In Julyhe voluntarily resigned from the CNR, since at the time he was investigating a high-profile case of scientific misconduct involving that institution. In JulyBucci left Biodigitalvalley and founded Resis Srl, a company dedicated to research integrity. He is co-author of chapters in scientific books and he is author of a book dedicated to scientific fraud, published in September His work on detecting scientific fraud has been covered by several national and international magazines, including Nature,and has been broadcast by the Italian State TV RAI.
Activities include the screening of papers connected to misconduct allegations, the pre-publication analysis of papers on a voluntary basis and the analysis of publications connected to public competition for granting and career advancements.
He is image editor in charge of integrity checking of figures to be published by some biomedical journals NPG group and others. Biomarkers for diagnosing and detecting the progression of neurodegenerative disorders, in particular of amyotrophic lateral sclerosis more.
The present invention relates to biomarkers, to their use and to a method for detecting the progression of a neurodegenerative disease in an individual, in particular for Amyotrophic Lateral Sclerosis ALS.
The method comprises the steps of quantifying the level of one or more polypeptides in the biological sample according to the invention; comparing the obtained level with a reference level. Xylella fastidiosa, a new plant pathogen that threatens global farming: Ecology, molecular biology, search for remedies more.
Enrico Bucci | Temple University –
Recently, the emergence of an important alien plant pathogen in Europe was evident when the Olive Quick Elettromagnehici Syndrome OQDSa previously unknown disease causing rapid scorching and death of the trees, invested with particular Recently, the emergence of an important alien plant pathogen in Europe was evident when the Olive Quick Decline Syndrome OQDSa previously unknown disease causing rapid scorching and death of the trees, invested xampi particular virulence a substantial portion of the vast olive wood of Southern Italy Salento, part of the Apulia region.
Early evidence indicated a connection between the OQDS and the gram-negative bacterium Xylella fastidiosa. This bacterium can target several important crops, so that researchers from all over the world have investigated its association with host plants and vectors, the molecular biology of the infection mechanism, and the molecular reaction of the infected plants.
Potentially resistant or tolerant cultivars and molecular targets which might be useful to control the infection have been identified. In vitro tests of compounds active against Xylella have also been performed.
In this contribution, the literature and the available data will be reviewed to provide an up-to-date picture of the currently available knowledge on the role of Xylella in OQDS, and in diseases of other plants, with focus on the emerging threats to European farming.
Biochemical and Biophysical Research Communications. What is scientific fraud? Nowadays, since scientific fraud is perceived as a serious societal threat, it is quite easy to find articles which pose the question of whether research misconduct should be considered a criminal offence and how would it be possible to Nowadays, since scientific fraud is perceived as a serious societal threat, it is quite easy to find articles which pose the question of whether research misconduct should be considered a criminal offence and how would it be possible to proceed in a criminal trial against fraudsters.
When discussing these topics, however, it happens to forget that scientific fraud still lacks a univocal definition, a fact which undermines its possible criminalization. In other words, often the borders between error, misconduct and true scientific fraud are not sufficiently clear, so that identifying and punishing researchers whose professional behaviour was bad is considerably complicated by this lack of clarity. Which is the most appropriate pu- nishment? These questions clearly identify the problem.
In this paper, we would like to bring to the attention of the reader some of our ideas on these topics. We would like to explicitely state that misconduct in science is never acceptable, but in order buccii proceed against serious offences it is necessary to weight the observed behaviour in an appropriate manner. To avoid some dangerous ethical and conceptual traps, we aim to introduce here a few elettromagnefici useful to examine any allegation of research misconduct.
The Future of Science and Ethics. Research Misconduct and Research Integrity. Automatic detection of image manipulations in the biomedical literature more. Images in scientific papers are used to support the experimental description and the discussion of the findings since several centuries.
In the field of biomedical sciences, in particular, the use of images to depict laboratory results is In the field of biomedical sciences, in particular, the use of images to depict laboratory results is widely diffused, at such a level that one would not err in saying that there is barely any experimental paper devoid of images to document the attained results.
With the advent of software for digital image manipulation, however, even photographic reproductions of experimental results may be easily altered by bycci, leading to an increasingly high rate of scientific papers containing unreliable images. In this paper I introduce a cam;i pipeline to detect some of the most diffuse misbehaviours, running two independent tests on a random set of papers and on the full publishing record of a single journal. The results obtained by these two tests support the feasibility of the software approach and imply an alarming level of image manipulation in the published record.
Recent aggressive chemotherapeutic and combined treatments have resulted in increased survivorship for advanced stage breast cancer. In some patients, treatment produces an actual abatement of their cancer, while in others treatment In some patients, treatment elettdomagnetici an actual abatement of their cancer, while in others treatment mitigates the progression of cancer bringing those patients into palliative care where their chronic disease requires continuous management.
There is also evidence elettromagntici the majority of palliative-care cancer patients have a deteriorating quality of life that only precipitously declines in the final few weeks of life. The new paradigm of patient-centered care for palliative patients is resulting in a new model of treatment in which the self-efficacy seems to play an important role. The present study represents an extension of the role of self-efficacy for coping to palliative care.
Using a stress-coping model, the primary aim of this ccampi was to evaluate a process model, in which self-efficacy for coping with cancer is a moderator between stress and the quality of life in a sample of breast cancer patients in palliative care. The elettromagnrtici aim was to validate a specific eletttromagnetici coping self-efficacy scale, the Cancer Behavior Inventory.
The current study confirmed the role of self-efficacy for coping with cancer as moderator of the relationship between stress and quality of life of a sample of breast cancer patients in palliative care. In addition, this study confirmed the structure, reliability and validity of the scale.
Anticancer research Page Numbers: Alice is an engineer who elettromagentici into the research world of life sciences.
To her eyes, life sciences researchers work backwards compared to what happens in her world. It appears that their research methodology has a number of issues It appears that their research methodology has a number of issues that may limit its potential.
Nevertheless, she also becomes aware that a different set of problems arises if her own traditional top-down engineering approach is applied to life sciences. This article discusses how the authors see the role of systems and computational biology bucxi a fundamental methodological “middle-ground” between these two apparently distant worlds. This article is part of a special issue on life sciences computing.
IT Professional Page Numbers: Engineering Challenges in the World of Life Sciences more. Amyotrophic lateral sclerosis ALS is a progressive, fatal neurodegenerative disease caused by the degeneration of motor neurons. This phenomenon is likely to be correlated to the degeneration observed elettromagnetjci these regions.
Moreover, a statistical analysis allowed us to highlight other proteins as differentially expressed among the three mice groups analyzed. Some of them were identified by reverse-phase HPLC fractionation of extracted proteins and mass spectrometric analysis before and after trypsin digestion.
Journal of proteome research. An Engineer ‘ s Perspective more. Proceedings of the IEEE. Electromagnetism, Nanotechnologies and Biology: New Challenges and Opportunities more. This paper reviews the possibilities offered by the advent of nanotechnology for regulating the interaction between electromagnetic fields and bio-systems with unprecedented flexibility and specificity.
In particular, we discuss how the In particular, we discuss how the exploitation of magnetic nanoparticles and magnetic fields can lead to significant advances in clinical and diagnostic applications, and to the opening of a completely new scenario: Design and conformational studies.
The objective of our study was to mimic in a typical reductionist approach the molecular interactions observed at the interface between the gp elettromqgnetici and interleukin-6 during formation of their complex. A peptide system obtained by The CD titration experiments demonstrated that the interaction between the designed peptides is specific and based on a well-defined stoichiometry. The NMR data confirmed some of the structural features of the binding mechanism as predicted by the rational design and indicated that under our conditions the recognition specificity and affinity can be explained by the formation of a two-helix bundle.
Journal of peptide science. The search for new oligonucleotides with improved properties represents an important step for the development of oligonucleotides as powerful biomolecular tools, antisense and antigene agents, molecular probes and biosensors.
PNA mimics the behaviour of DNA and binds complementary nucleic acid strands, with higher affinity and specificity than corresponding oligonucleotides.
The unique properties of PNA open up novel molecular biology and biochemistry applications that are unachievable with traditional oligonucleotides and peptides. PNA oligomers are resistant to degradation by enzymes, and the lifetime of these compounds is extended both in vivo and in vitro.
The direction of rational drug design of new PNA with specific functions depends critically on understanding the basic principles of specificity of biomolecular recognition for this class of molecules.
Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity more. In this work, we report the synthesis of an alternate nucleo-alpha,epsilon-peptide based on L: The efficiency of the novel nucleo-alpha,epsilon-peptide in interfering bucfi the reverse transcription of eukaryotic eoettromagnetici and the elettrkmagnetici enzymatic resistance demonstrated by specific assays are in favor of the employment of this nucleopeptide in elettgomagnetici biomedical strategies.
In this work, we report the synthesis of a novel Fmoc-protected nucleoaminoacid, based on 4-piperidinyl glycine, carrying the DNA nucleobase on the secondary amino group, suitable for the solid-phase synthesis of nucleopeptides.
After ESI-MS and NMR characterization this building block was used for the assembly of a thymine-functionalized tetrapeptide, composed of 4-piperidinyl glycine and L-arginine moieties alternated in the backbone.
As part of our research on new oligonucleotide analogs for therapeutic and diagnostic use, here we explored the ability of an alternate dab-aegPNA oligomer to bind complementary natural nucleic acids.
The alternate homothymine dab-aegPNA, The stoichiometry of the complexes formed was determined by CD titration experiments that suggested triple helices formation. With respect to an analogous t 12 strand composed entirely of aegPNA, the chiral alternate t 12 oligomer presented an enhanced solubility in aqueous medium and did not form aggregates. Human serum stability assays performed on the new alternate oligomer evidenced bucdi noteworthy enzymatic resistance.
Journal of Medicinal Chemistry.