BRINTELLIX PACKAGE INSERT PDF

This leaflet answers some common questions about Brintellix. Do not take Brintellix if the packaging is torn or shows signs of having been tampered with. Product details on treatment with TRINTELLIX (vortioxetine), including available savings if eligible, and support sign-up. Watch videos of actual patients. See full. Attachment 1: Product information for AusPAR vortioxetine hydrobromide Brintellix Lundbeck Australia Pty Ltd PM Final 8 July.

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Patients who were excluded had a current psychiatric disorder other than MDD; a current or past history of mania or hypomanic episode, schizophrenia, or any other psychotic disorders; mental retardation, organic mental disorders, or mental disorders due to a general medical condition; any current diagnosis of substance abuse or dependence; and any neurological or neurodegenerative disorders.

Agonist and partial agonist activity at these two receptors can lead to further serotonin release and could theoretically cause additional antidepressant activity.

Possible side effects 5. The tablet can be taken with or without food.

It is also contraindicated when vortioxetine is stopped and MAOIs will be prescribed within 21 days. Brintellix should not be given to children bribtellix 18 years of age. Some medicines and Brintellix may interfere with each other. Brintellix is not to be used during breast-feeding.

BRINTELLIX┬« (vortioxetine) tablets – GlobalRPH

Red, almond-shaped 5 x 8. Tell your doctor if you notice any of the following side effects and they worry you: Last updated on eMC: However, as adverse reactions such as diziness have been reported, caution is advised during such activities when beginning Brintellix treatment or changing the insrt.

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This study sought to determine the efficacy and tolerability of vortioxetine as an effective maintenance treatment to prevent relapses of MDD. Based on the receptor binding affinities, vortioxetine displays reuptake blockade of the insery transporter, agonist activity at the 5-HT 1A receptor, partial agonist activity at the 5-HT 1B receptor, and antagonism at the 5-HT 1D5-HT 7and 5-HT 3 receptors.

The primary endpoint was evaluation of the efficacy, tolerability, and safety of two fixed doses of vortioxetine versus pacoage in moderate-to-severe MDD. Vortioxetine has a linear pzckage dose-proportional pharmacokinetic profile with single daily dosing of 2. In the open-label, flexible-dosing week phase, there was a statistically significant change in baseline from the MADRS score of Things to be careful of Be careful driving or operating machinery until you know how Brintellix affects you.

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Drug interactions involve inhibitors and inducers of CYP2D6. Ask your doctor or pharmacist if you are unsure of the correct dose for you. Reference Package insert data: Pink, almond-shaped 5 x 8. You must wait at least one day after finishing moclobemide before you start Brintellix.

Curr Med Res Opin. Please tell your doctor if you are taking any of the medicines above, since your doctor needs to know if you already are at risk for seizures.

Vortioxetine acts as an agonist at the 5-HT 1A receptor and a partial agonist at the 5-HT 1B receptor, both of which function as autoreceptors for serotonergic neurotransmission. Consumption of food does not affect the bioavailability, and taking vortioxetine with food has not been shown to increase its peak concentration C max. Based on clinical trial data, vortioxetine has been shown to be an effective initial and maintenance treatment for major depressive disorder.

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Brintellix tablets 5, 10 and 20mg

It may harm them, even if their signs of illness are the same as yours. Vortioxetine has been known to cause an increase in the risk of bleeding because of interference with ihsert reuptake. Vortioxetine HBr is known chemically as 1-[2- 2,4-Dimethyl-phenylsulfanyl -phenyl]-piperazine, hydrobromide. Treatment should be discontinued in any patient who develops fits or where there is an increase in the frequency of fits.

The rapid recovery of 5-HT insetr firing induced by the antidepressant vortioxetine involves brinellix 3 receptor antagonism. Taken as directed, this medication displays efficacy similar to other antidepressants studied in recent years and tends to be well tolerated, displaying an adverse-effect profile similar to other serotonergic antidepressants on the market.

Heat and dampness can destroy some medicines. These symptoms usually begin during the first 24 hours after the baby is born. Tell your doctor if you are receiving electroconvulsive therapy.

Taking other medicines Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Investigators were permitted to increase the dose if clinically necessary during weeks 2 through 8.

Your doctor will check your progress at regular intervals. All medicines have risks and benefits.